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25 The Val 23 and Ile 27 used in tirzepatide are likely to have little impact on either GLP-1 or GIP activity because they are the same kind of residue and no specific interaction in these sites has been detected

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"Our post-hoc analysis of Surmount-4 found that 82.5 percent of participants who stopped tirzepatide regained at least 25 percent of their lost weight within a year, which is consistent with other studies referenced in the paper