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The realistic routes are hydrolysis and deamidation with heat and humidity, aggregation of the acylated peptide at higher concentrations or after agitation, and adsorption losses to tube and plate surfaces at low working concentrations — the last being a common cause of dose–response curves that drift between runs for no visible reason
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The trial also showed improvements in blood pressure and cardiovascular risk markers, extending the drug's potential benefits beyond weight and glucose alone
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