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five half-lives is 25 days Most centers use a buffer beyond the elimination estimate Some centers wait until weight has stabilized after discontinuation to assess overall donor health Typical deferral windows we have seen in 2026: Conservative centers: 6 months after last dose Standard policy at major chains: 12 weeks after last dose Some centers: 8 weeks after last dose with medical director approval If you are planning to donate plasma and currently on Ozempic, the practical question is whether you're willing to discontinue for the required window
