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The intestine functions as a reward-sensing organ, peripheral physiology sets motivational drive, and central dopamine circuits are the final common pathway through which addiction is expressed
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In a phase II trial, tirzepatide once weekly was superior to dulaglutide in terms of HbA1c reduction and body weight reduction in patients with T2D with safety data for tirzepatide similar to that of GLP-1RAs (87)
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