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In a new study reported in The Lancet, Tirzepatide, a GLP-1R/GIPR agonist, reduced alcohol's rewarding properties, locomotor stimulation, conditioned place preference, and accumbal dopamine release
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Particularly noteworthy is that in patients with both type 2 diabetes and MASLD, after 24 weeks of treatment with a 10 mg dose of efinopegdutide, liver fat content reduced by 72.7%, a result that is superior to the 42.3% reduction achieved with a 1 mg dose of semaglutide, despite a similar overall weight loss being observed with the two interventions
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