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These effects were coupled to an amelioration in lipid metabolism and hepatic steatosis, which markedly exceeded the effect of single GLP-1RA treatment ( Oxyntomodulin, a gut-derived peptide hormone, activates both the GLP-1R and the GCGR, although, with reduced affinity compared to GLP-1 and glucagon, respectively
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Persistent nausea lasting beyond the first few weeks of therapy, vomiting more than twice daily, or diarrhea occurring more than three times daily significantly increases electrolyte loss risk
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