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A clinical challenge is that intentional weight reduction, whether through lifestyle intervention or additional treatment with OMMs, eventually levels out or “plateaus.” Given that clinically meaningful body weight reduction is considered 5% or greater [36, 37] and given that 1%–2% change in body weight is considered a normal physiological fluctuation [38], it could be postulated that a less than 5% body weight change within 3 months following an initial intentional body weight reduction during the 60‐week weight‐loss period might reasonably reflect a clinical body weight plateau, which is the definition used in this study
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