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Aetna's medical policy bulletin CVS-082 (updated January 2026) states: "Tirzepatide (Mounjaro) is considered medically necessary for the treatment of type 2 diabetes mellitus when criteria are met
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8 GLP-1 analogs on alpha-cells and liver: Glucagon production GLP-1 analogs also exert some of their most important effects on the pancreatic alpha-cells and liver
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