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One second study evaluated exenatide and oxycodone in mice and reported that the systemic injection of exenatide into the NAcc shell reduced oxycodone self-administration and responses in a reinstatement paradigm

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The dose of semaglutide injections (Wegovy and Ozempic) starts from 0.25 mg weekly for the first four weeks and escalated to 0.5 mg weekly for the next four weeks