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Beyond thyroidal hyperfunction, Graves’ disease may manifest with extra-thyroidal complications, most notably thyroid-associated orbitopathy, in which fibroblasts and preadipocytes in the orbit express the TSHR and insulin-like growth factor 1 receptor (IGF-1R), leading to tissue expansion, edema, and fibrosis under autoantibody stimulation [19,20]
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Human studies in other chronic pain conditions, including neuropathic pain syndromes, have shown measurable pain reduction and improved function with GLP-1 therapy
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