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For instance, preliminary findings from the phase 2 trial of retatrutide, a triple hormone receptor agonist, reported a 100% response rate of more than 5% weight loss for the dosages of 8 or 12 mg weekly over 48 weeks ( Figure 2 To date, little is known about specific predictive factors for treatment response, especially for pharmacotherapy ( Research has indicated that the presence of type 2 diabetes significantly impacts weight loss response ( post-hoc analysis of pooled data from the SCALE Obesity and Prediabetes and SCALE Diabetes trial demonstrated notable differences in the proportion of ‘early responders’ and ‘early non-responders’ to liraglutide

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For patients struggling with insulin resistance, this leads to a more efficient metabolism and easier weight management