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“And if you take two items that lower blood sugar at the same time, you could have a problem like excessive hypoglycemia, when blood sugar crashes.” In addition, berberine is “directly antimicrobial,” which was its most common use in historical herbal medicine, Levitt said: “Antimicrobial effects can irritate the GI tract so unless a person has an overgrowth of bad bugs it can cause digestive distress.” Berberine can be dangerous if taken with cyclosporine, an immunosuppressive drug used to treat organ rejection post-transplant, as it might heighten that drug’s effects and possible side effects

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