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retatrutide triple agonist gip glp-1 glucagon phase 3 2025 mechanism receptor just had its biggest data year yet. In 2026, Eli Lilly's GLP-1/GIP/ glucagon posted Michael Weintraub, MD on X: –

GLP-1 activates vagal afferent neuronal activity and administration of GLP-1r antagonists into the portal vein impairs glucose tolerance (234) suggesting that the peripheral nervous system is also important in mediating GLP-1 effects on glucose homeostasis

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