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Finally, to strengthen the GLP1-RAs potential benefit effect on HPG axis, in studies conducted in obese PCOS women treated with GLP1-RAs (liraglutide and exenatide), amelioration of insulin resistance, reduction of hyperandrogenemia, improvement of ovulation rates, and restored menstrual cyclicity were observed ( DPP4 Inhibitors (DPP4is): Evidence on Their Effects on Male HPG Axis DPP4is are a relatively new class of oral diabetes drugs, also known as gliptins

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Weight loss itself is associated with reduced cancer risk for several types of cancer, including colorectal, breast, and liver cancers