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By April 2025, there were 480 reports of adverse events linked to compounded tirzepatide, including 10 deaths potentially tied to compounded GLP-1 receptor agonists

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In two studies, pioglitazone was used as monotherapy (84, 85), one study allowed rosiglitazone or pioglitazone as monotherapy (86), in one study pioglitazone was used alone or with metformin and/or sulfonylurea (87) and one study used pioglitazone with metformin (88)