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In weight-reduction trials, common adverse reactions included nausea, diarrhea, vomiting, constipation, abdominal pain, and dyspepsia

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These findings were corroborated by in vitro experiments showing similar GLP-1 receptor signalling properties of GLP-1–MK-801 and GLP-1–inactive MK-801 compared with lipidated analogues of GLP-1, semaglutide and liraglutide, and the parent GLP-1 analogue (Fig