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After four weeks of PEX-168 therapy at various doses, a multicenter, multiple dose-escalation RCT demonstrated weight reduction of −0.8–1.8 kg
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It was found that more patients in the LIR group than the placebo group maintained their weight loss by ≥5%, which indicated that LIR 3.0 mg/d is expected to improve the maintenance of weight loss (93)
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