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However, unlike the natural hormone, which breaks down in minutes, agonists are chemically modified to resist degradation, allowing them to remain active in the body for hours or days to provide continuous metabolic control
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The evidence base includes STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
