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Relative to placebo, tirzepatide was also associated with significant improvements in BMI, HbA1c, fasting glucose, fasting insulin, lipid levels, and systolic and diastolic pressure, which emphasizes the need to continue pharmacotherapy to prevent weight regain and ensure the maintenance of cardiometabolic benefits (Aronne et al
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Bitter taste receptors: Key target to understand the effects of polyphenols on glucose and body weight homeostasis
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