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This rapid signal, mediated by neuropod cell release of glutamate onto VANs, provides nearly instantaneous spatial and temporal information on a meal, which can then be followed by more traditional gut peptide–vagal afferent signaling pathways outlined below 95,96

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Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications