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A recent review analyzed the role of DPP-4is in patients with T2D and HF, highlighting some controversial results, since some data indicate an increased risk of HF hospitalizations with specific DPP-4is (e.g., saxagliptin), while others report neutral effects, which could indicate effects more related to specific individual molecular characteristics than to a generic common effect of the entire class of drugs [150]

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A major concern for athletes has been muscle loss during GLP-1 therapy