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According to the American Diabetes Association (ADA) Standards of Care, a GLP-1 RA should be considered in T2D patients who have not met glycemic goals on metformin, especially if additional factors are present such as atherosclerotic cardiovascular disease (ASCVD), heart failure, or chronic kidney disease
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The [Ca 2+ ] i increases with amplitudes twice larger than fluctuations of baseline or greater were considered as responses
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