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As the authors point out, long-term proton pump inhibitor use is connected to serious side effects and increases the risk of some other potentially serious conditions such as Clostridium difficile associated diarrhea, osteoporosis, and vitamin or electrolyte malabsorption
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In addition, a large-scale clinical study demonstrated that GLP-1 analogues could reduce the mortality of patients with prostate cancer and diabetes (19)
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