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In two studies, tirzepatide was undetectable in approximately 96 percent of milk samples and present only in negligible amounts (less than 0.02 percent of the maternal dose) in the remaining samples
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Miller and Scanlan later introduced an efficient solid-phase synthesis approach, where free amines were activated with an o -nitrobenzenesulfonyl group, followed by direct methylation using methyl p -nitrobenzenesulfonate