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If genuine tachyphylaxis is confirmed, strategies include dose escalation to the next tier, brief treatment breaks of 2 to 4 weeks to allow receptor resensitization, or switching to alternative GLP-1 agonists like semaglutide to provide different receptor activation patterns
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Medication:Tirzepatide (GLP-1 + GIP)
doi: 10.1186/s12967-022-03629-8
