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The STEP program, including the STEP 1 and STEP 3 trials, demonstrated that semaglutide at a 2.4 mg weekly dose resulted in an average weight loss of approximately 15% from baseline—a result that many of us could only dream of achieving with lifestyle changes alone.⁴ In the STEP 4 extension study, continued semaglutide treatment was shown to sustain weight loss, while discontinuation led to gradual weight regain, highlighting the importance of long-term therapy.⁵ As a pharmacist, I’ve seen firsthand how patients respond to these medications