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Figure 3 Kynurenine was demonstrated to cross the BBB and was implicated in the pathophysiology of disorders marked by impulsivity, including schizophrenia, ADHD, cognitive disorders, drug addictions, and mania (205)

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The risk posed by these drugs in humans remains unclear (6), and there is conflicting evidence regarding GLP-1R expression by human C-cells (4, 7, 8) and their safety (9)