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In a rat model of diabetes-induced testicular dysfunction, liraglutide reduced testicular TGF-β and Smad2 mRNA expression levels [26], whilst in HUVECs, liraglutide attenuated high glucose and IL-1β-induced TGF-β signalling (via inhibition of Smad2 phosphorylation), leading to reduced endothelial-to-mesenchymal transition (EndMT) marker expression [27]
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