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Common side effects In the SUSTAIN trials, the most frequently reported side effects with semaglutide were: 5 Nausea: 11-20% of participants (compared to 3-8% with placebo) Diarrhoea: 4.5-11% of participants Vomiting: 4-11.5% of participants Constipation: Common, particularly in early weeks These side effects are typically mild to moderate and tend to improve as your body adjusts to the medication
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