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Real-world evidence from a registry of 3865 T2DM patients showed that those treated with GLP-1 agonists had a 28% lower incidence of heart failure hospitalization compared to other glucose-lowering therapies, with the benefit being most pronounced in patients with subclinical diabetic cardiomyopathy detected by elevated NT-proBNP levels [83]

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Generic semaglutide can reduce the cost barrier, but the overall treatment quality still depends on the brand, dose schedule, device type and clinical follow-up