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freezing can cause irreversible peptide aggregation Avoid temperature fluctuations — do not repeatedly remove the vial from and return it to the fridge If a temperature excursion occurs (e.g., the fridge fails or the vial is left out), do not attempt to judge suitability yourself — contact your trial team or dispensing pharmacy immediately for advice before using the preparation If transport is required , use only sponsor-provided or validated cool carriers

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