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Lastly, the closeness_centrality assesses how close a vertex is to all other vertices in the graph, while also considering the edge weights and normalizing the result

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TIR decreases the glycated hemoglobin level in T2DM patients more efficiently than the GLP-1 RA semaglutide [14, 15], can significantly improve systemic insulin sensitivity [16], and is very effective in overcoming insulin resistance [17]