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The primary hypoglycaemia risk from alcohol is most relevant when retatrutide is used alongside insulin or sulfonylureas, as alcohol can independently lower blood glucose and may compound the glucose-lowering effects of these agents

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74 Gaykema and colleagues have provided evidence that noxious and nutritional stimuli activate distinct subsets of rat hindbrain GCG neurons, 40 and a similar comparative approach could be applied to intraintestinal nutrients versus gastric distension