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Transparency and preregistration of outcomes, particularly for ongoing large-scale efforts such as EVOKE and EVOKE+ (evaluating semaglutide in over 1800 participants with early Alzheimerโs disease) [110], will be crucial to resolving these uncertainties
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These are promising results, but the studyโs authors note that more research is needed, and โclinicians must also consider potential adverse effects, evaluate the cost-effectiveness of these medications for each patient, and closely monitor for any improvement or worsening of eating disorders and related side effects.โ That hesitation is shared by the National Eating Disorder Association (NEDA), who published an opinion paper on GLP-1s and eating disorders in 2024, stating: โWhile there is some evidence that GLP-1โs can decrease the number of binge eating episodes for those with BED, little is known about the long term physical and psychological impact on those with eating disorders.โ How GLP-1s could also fuel eating disorders The same mechanisms that make these medications helpful for some could make them harmful for others