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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market — but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial

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The CNPV program may play an increasingly important role in speeding up access to therapies that address urgent health challenges