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Discard your reconstituted retatrutide if any of the following apply: 28 days have passed since the reconstitution date — even if there's peptide left in the vial Cloudiness that won't clear after gentle swirling for several minutes Visible particles or flakes floating in the solution (not powder that will dissolve with more swirling) Unusual color change — a slight yellow tint is normal, but brown, orange, or dark discoloration is not Stopper damage — if the rubber stopper looks cored, cracked, or heavily pitted from multiple punctures Left at room temperature for more than a few hours — the benzyl alcohol preservative can't compensate for prolonged warmth When in doubt, discard it

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Most people will start to notice results within the first few weeks of treatment, but the most noticeable weight loss occurs after 3 to 6 months