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If you are already prescribed topiramate , contact your GP or neurologist promptly if you experience: Sudden changes in vision or eye pain — this may indicate acute angle-closure glaucoma and requires urgent same-day medical assessment Significant mood changes, persistent low mood, or any thoughts of self-harm Symptoms suggestive of kidney stones, such as severe flank or loin pain, or blood in the urine Persistent cognitive difficulties — such as problems with memory, concentration, or word-finding — that are affecting your daily life or work Fever with reduced sweating, which may indicate oligohidrosis and risk of overheating Rapid or laboured breathing, unexplained fatigue, or cardiac symptoms, which may suggest metabolic acidosis Any possibility of pregnancy, or if you are planning to become pregnant Do not stop taking topiramate suddenly

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T., & Yue, J