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In a study by Banks and colleagues (97) comparing the brain uptake pharmacokinetics of GLP-1R agonists, the acylated GLP-1R ligands liraglutide and semaglutide did not measurably cross the BBB, whereas the non-acylated and non-PEGylated GLP-1R ligands exendin-4 and lixisenatide did measurably cross the BBB (97)
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