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Results from a post hoc subgroup analysis of the SURMOUNT-1 study (NCT04184622), published this year [87] , demonstrated that among 32 pathogenic MC4R variant carriers (1.4% of the study population) with a median age of 41.06 years and a BMI ≥ 40 kg/m 2 , treatment with tirzepatide for 72 weeks resulted in an 18.3% reduction in body weight from baseline
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Indeed, it prominently occupies a spot in the top 10 most frequently occurring nitrogen heterocycles of FDA approved drugs in the US 1
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