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NEJM 2024) showed semaglutide 1.0 mg weekly reduced major kidney disease events and death by 24% in patients with type 2 diabetes and chronic kidney disease The FDA expanded Ozempic's label in 2025 to include renal risk reduction in adults with type 2 diabetes and CKD FLOW was stopped early for efficacy at interim analysis Non-diabetic CKD is not part of the approved indication
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Therefore, GLP‐1 receptor agonists resistant to the proteolytic inactivation by DPP‐4 (e.g