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Mechanisms of Action of GLP-1RAs: Beyond Glycaemic Control Endogenous glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by intestinal L cells and brainstem neurons in response to nutrient intake

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Triple agonists take the next step by simultaneously activating: GLP-1 receptors GIP receptors Glucagon receptors Each receptor contributes unique metabolic effects