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GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal.
The amino acid sequence of liraglutide is 97% homologous to GLP-1, and the lysine at position 26 is connected to a 16-carbon fatty acid, which not only enhances the resistance of liraglutide to the degradation of DPP-4, but also provides a slow release effect, extending the half-life to 10~14 h
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