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What the Liver Fat Research Shows The liver signal is the best-quantified non-weight finding in the retatrutide literature, and it comes from a single dedicated publication: a randomised, double-blind, placebo-controlled phase 2a substudy of the 48-week obesity trial, in 98 participants who had metabolic dysfunction-associated steatotic liver disease (MASLD) and at least 10% liver fat at baseline (DOI)