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The neuroprotective activities of GLP-1RAs against PD can be, at least partially, mediated by PI3K/AKT pathway that modulates several downstream molecules, such as cAMP response element-binding protein (CREB), glycogen synthase 3β (GSK-3β), Forkhead box O1/O3 (FoxO1/O3), and mammalian target of rapamycin (mTOR) (Athauda and Foltynie, 2016) (Figure 1B)