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A study analyzing the data from the US Department of Veterans Affairs database found that male patients with T2D (majority Caucasian males) who initiated GLP-1 medicines ( n = 215,970) had a lower risk of seizure (HR: 0.90, 95% CI: 0.85–0.95) compared to patients who continued the use of other glucose-lowering drugs (GLDs) ( n = 1,203,097) over a median of 3.68 years
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While some patients may perceive mood changes during tirzepatide therapy, current clinical evidence does not establish a direct link between tirzepatide and anger or irritability specifically
