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The endogenous ligand GLP-1, did not demonstrate detectable bias, whereas P5 yielded bias factors ( β ), of 0.9 and 1.4 for Gαs-protein over β-arrestin 1 and -2, respectively, and of 1.7 and 2.4 for Gαq-protein over β-arrestin 1 and -2, respectively (Fig
