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The amino acid sequence of human insulin allows the process of misfolding to take place, where monomeric insulin initially forms soluble oligomers rich in β-sheet structures, which might be cytotoxic
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18 GLP-2, also secreted by enteroendocrine L-cells, differs from GLP-1 and GIP in that it appears to have less influence on metabolic control and primarily functions as an intestinotrophic factor, helping maintain intestinal health