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Tirzepatide, being a peptide-based medication, is broken down through proteolysis (protein degradation) rather than hepatic metabolism
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Although the original study protocol used the terms ‘5-component nephropathy composite’ and ‘acute renal failure’, here, we rephrased these as ‘5-component kidney composite’ and ‘acute kidney failure’, in line with recent nomenclature guidance introduced since the writing of the protocol 53
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