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When these peptides attach to their respective receptors in the ARC, they activate anorexigenic proopiomelanocortin (POMC) neurons and stimulate POMC processing resulting in α-melanocyte-stimulating hormone (α-MSH) release [6, 7] leading to satiety, primarily via α-MSH-mediated activation of melanocortin 3 and 4 receptors [8‐10]
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