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When blood glucose (BG) concentrations are normal or high, the intestines secrete GLP-1 and GIP to act on pancreatic beta cells through intracellular signaling pathways that involve cyclic adenosine monophosphate (cAMP)

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Dose-dependent increases in heart rate were also observed, consistent with the glucagon receptor agonism component of the drug, and this warrants careful monitoring in individuals with pre-existing cardiac conditions